Jalan Cerita:
FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.

Pemain:

Samuel L. Jackson Neville Flynn

Julianna Margulies Claire Miller

Nathan Phillips Sean Jones

Kenan Thompson Troy

Rachel Blanchard Mercedes