Jalan Cerita:
After being bitten by a genetically altered spider at Oscorp, nerdy but endearing high school student Peter Parker is endowed with amazing powers to become the superhero known as Spider-Man.

Pemain:

Tobey Maguire Spider-Man / Peter Parker

Willem Dafoe Green Goblin / Norman Osborn

Kirsten Dunst Mary Jane Watson

James Franco Harry Osborn

Cliff Robertson Ben Parker