Jalan Cerita:
Newly-paroled former US Army ranger Cameron Poe is headed back to his wife, but must fly home aboard a prison transport flight dubbed "Jailbird" taking the “worst of the worst” prisoners, a group described as “pure predators”, to a new super-prison. Poe faces impossible odds when the transport plane is skyjacked mid-flight by the most vicious criminals in the country led by the mastermind — genius serial killer Cyrus "The Virus" Grissom, and backed by black militant Diamond Dog and psychopath Billy Bedlam.

Pemain:

Nicolas Cage Cameron Poe

John Malkovich Cyrus "The Virus" Grissom

John Cusack Agent Vince Larkin

Ving Rhames Nathan "Diamond Dog" Jones

Mykelti Williamson "Baby-O" O'Dell