Jalan Cerita:
Cady Heron is a hit with The Plastics, the A-list girl clique at her new school, until she makes the mistake of falling for Aaron Samuels, the ex-boyfriend of alpha Plastic Regina George.

Pemain:

Lindsay Lohan Cady Heron

Rachel McAdams Regina George

Lizzy Caplan Janis Ian

Lacey Chabert Gretchen Wieners

Amanda Seyfried Karen Smith