Jalan Cerita:
The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.

Pemain:

Tobey Maguire Spider-Man / Peter Parker

Kirsten Dunst Mary Jane Watson

James Franco New Goblin / Harry Osborn

Thomas Haden Church Sandman / Flint Marko

Topher Grace Venom / Eddie Brock