Jalan Cerita:
Stuart, an adorable white mouse, still lives happily with his adoptive family, the Littles, on the east side of Manhattan's Central Park. More crazy mouse adventures are in store as Stuart, his human brother, George, and their mischievous cat, Snowbell, set out to rescue a friend.

Pemain:

Michael J. Fox (suara) Stuart Little

Melanie Griffith (suara) Margalo

Nathan Lane (suara) Snowbell

Geena Davis Mrs. Little

Hugh Laurie Mr. Little